Name : Human TGM2 Protein
Product Source :
Recombinant Human TGM2 Protein is expressed from E.coli with His tag at the N-Terminus. It contains Ala2-Ala687.[Accession | P21980-1]
Molecular Weight :
The protein has a predicted MW of 78.4 kDa same as Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Supplied as 0.22μm filtered solution in 20mM Tris, 500mM NaCl, 10% Glycerol (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human TGM2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. ELISA Data Immobilized Human TGM2, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-TGM2 Antibody, hFc Tag with the EC50 of 9.3ng/ml determined by ELISA.
Background :
Transglutaminase 2 (TGM2) is a member of the transglutaminase family, and it is reported to be associated with chemoresistance in various types of cancer. TGM2 was demonstrated to affect the chemosensitivity of osteosarcoma cells via regulation of the activation of mitogen‑activated protein kinase and AKT serine/threonine kinase pathways.
Synonyms :
TGM2; tTG; tTgase; TGC; TGase C; TGase II; TG2; G-ALPHA-h; GNAH; HEL-S-45; TGase-2; TGase-H; TGCGNAH
References & Citations :
(1) Li C, Cai J, Ge F, Wang G. TGM2 knockdown reverses cisplatin chemoresistance in osteosarcoma. Int J Mol Med. 2018 Oct;42(4):1799-1808. doi: 10.3892/ijmm.2018.3753. Epub 2018 Jul 4. PMID: 30015899; PMCID: PMC6108886.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
OX40/TNFRSF4 Proteinmanufacturer
FCRL1 Proteinmanufacturer
Popular categories:
IFN-alpha/beta R2
VEGF-B