Name : Mouse TGM2 Protein
Product Source :
Recombinant Mouse TGM2 Protein is expressed from E.coli with His tag at the N-Terminus. It contains Ala2-Ala686.[Accession | P21981-1]
Molecular Weight :
The protein has a predicted MW of 78.2 kDa same as Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per ug by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse TGM2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse TGM2 is greater than 95% as determined by SEC-HPLC.
Background :
Transglutaminase 2 (TGM2) is a member of the transglutaminase family, and it is reported to be associated with chemoresistance in various types of cancer. TGM2 was demonstrated to affect the chemosensitivity of osteosarcoma cells via regulation of the activation of mitogen‑activated protein kinase and AKT serine/threonine kinase pathways.
Synonyms :
TGM2; tTG; tTgase; TGC; TGase C; TGase II; TG2; G-ALPHA-h; GNAH; HEL-S-45; TGase-2; TGase-H; TGCGNAH
References & Citations :
(1) Li C, Cai J, Ge F, Wang G. TGM2 knockdown reverses cisplatin chemoresistance in osteosarcoma. Int J Mol Med. 2018 Oct;42(4):1799-1808. doi: 10.3892/ijmm.2018.3753. Epub 2018 Jul 4. PMID: 30015899; PMCID: PMC6108886.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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