Name : Human TNFRSF19 Protein
Product Source :
Recombinant Human TNFRSF19 Protein is expressed from HEK293 with His tag at the C-terminus. It contains Glu30-Leu170.[Accession | Q9NS68-1]
Molecular Weight :
The protein has a predicted MW of 16.55 kDa. Due to glycosylation, the protein migrates to 25-40 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human TNFRSF19 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human TNFRSF19 is greater than 95% as determined by SEC-HPLC.
Background :
A novel susceptibility gene TNFRSF19, which encodes an orphan member of the TNF receptor superfamily known to be associated with nasopharyngeal carcinoma (NPC) and lung cancer risk. TNFRSF19, a susceptibility gene for nasopharyngeal carcinoma and other cancers, functions as a potent inhibitor of the TGFβ signaling pathway.
Synonyms :
TRADE; Toxicity and JNK inducer; Taj; Troy; AL023044; AW123854; TAJ-alpha; TAJ alpha
References & Citations :
Deng C, Lin YX, Qi XK, He GP, Zhang Y, Zhang HJ, Xu M, Feng QS, Bei JX, Zeng YX, Feng L. TNFRSF19 Inhibits TGFβ Signaling through Interaction with TGFβ Receptor Type I to Promote Tumorigenesis. Cancer Res. 2018 Jul 1;78(13):3469-3483. doi: 10.1158/0008-5472.CAN-17-3205. Epub 2018 May 7. PMID: 29735548.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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