Product Name: Vemurafenib (PLX4032, RG7204)
Subtitle: BRAF kinase inhibitor
Biological Activity: Biological Activity of Vemurafenib (PLX4032, RG7204)Description Vemurafenib (PLX4032, RG7204) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM. Targets B-RafV600E C-Raf MAP4K5 (KHS1) SRMS ACK1 FGR IC50 31 nM 48 nM 51 nM
SMLES: CCCS(=O)(=O)Nc1ccc(c(c1F)C(=O)c2c[nH]c3c2cc(cn3)c4ccc(cc4)Cl)F
CAS NO: 956104-40-8
Standard In CHIKey: Phosphatase_Inhibitor_Cocktail_I inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C23H18ClF2N3O3S
M.Wt: 489.93
General Tips: for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.PubMed ID:http://jpet.aspetjournals.org/content/255/1/17
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: Vemurafenib