Name : Cynomolgus TROP-2/TACSTD2 Protein
Product Source :
Recombinant Cynomolgus TROP-2/TACSTD2 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains His27-Thr274.[Accession | XP_005543292.1]
Molecular Weight :
The protein has a predicted MW of 28.7 kDa. Due to glycosylation, the protein migrates to 40-55 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Cynomolgus TROP-2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Cynomolgus TROP-2 is greater than 95% as determined by SEC-HPLC. ELISA Data Immobilized Cynomolgus TROP-2, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-TROP-2 Antibody, hFc Tag with the EC50 of 2.8ng/ml determined by ELISA.
Background :
Trop-2,also known as epithelial glycoprotein-1 antigen (EGP-1),is a protein that in humans is encoded by the TACSTD2 gene.Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.
Synonyms :
EGP1; EGP-1; TROP2; GA733-1; gp50; T16; TACSTD2; TROP-2; M1S1; TACD2
References & Citations :
(1)Zimmers SM, Browne EP, Williams KE, et al. TROP2 methylation and expression in tamoxifen-resistant breast cancer. Cancer Cell Int. 2018;18:94. Published 2018 Jul 6. doi:10.1186/s12935-018-0589-9
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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