Name : Mouse PTK7/CCK4 Protein
Product Source :
Recombinant Mouse PTK7/CCK4 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Ala23-Thr696.[Accession | Q8BKG3]
Molecular Weight :
The protein has a predicted MW of 75.67 kDa. Due to glycosylation, the protein migrates to 90-110 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse PTK7 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse PTK7 is greater than 95% as determined by SEC-HPLC.
Background :
Protein Tyrosine Kinase 7 (PTK7) is as a critical regulator of canonical and non-canonical Wnt-signaling during embryonic development and cancer cell formation. Disrupting PTK7 activity perturbs vertebrate nervous system development, and also promotes human cancer formation. Observations in different model systems suggest a complex cross-talk between PTK7 protein and Wnt signaling.
Synonyms :
CCK-4; PTK7
References & Citations :
(1) Lichtig H, Cohen Y, Bin-Nun N, Golubkov V, Frank D. PTK7 proteolytic fragment proteins function during early Xenopus development. Dev Biol. 2019 Sep 1;453(1):48-55. doi: 10.1016/j.ydbio.2019.05.007. Epub 2019 May 21. PMID: 31125531.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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