Name : Biotinylated Human CCR2b Protein-VLP

Product Source :
Recombinant Biotinylated Human CCR2b Protein-VLP is expressed from HEK293. It contains Met1-Leu360.[Accession | P41597-2]

Molecular Weight :
The target protein has a predicted MW of 42.9kDa.

Endotoxin Level :
Less than 1EU per μl by the LAL method.

Purity :
> 95% as determined by HPLC

Formulation :
Supplied as 0.22μm filtered solution in PBS, 300mM L-Arginine (pH 7.4).

Reconstitution :

Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Product Concentration :
SEC-HPLC The purity of Biotinylated Human CCR2b VLP is greater than 95% as determined by SEC-HPLC. SPR Data Biotinylated Human CCR2b VLP captured on SA Chip can bind Anti-CCR2b Antibody with an affinity constant of 5.24 nM as determined in SPR assay (Biacore T200).

Background :
The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammatory diseases. The actin-binding protein filamin A (FLNa) as a protein that associates with the carboxyl-terminal tail of CCR2B. FLNa emerges as an important protein for controlling the internalization and spatial localization of the CCR2B receptor in different dynamic membrane structures.

Synonyms :
C-C CKR-2; CCR-2; CCR2; MCP-1-R; CMKBR2; CCR2

References & Citations :
(1) Minsaas L, Planagumà J, Madziva M, Krakstad BF, Masià-Balagué M, Katz AA, Aragay AM. Filamin a binds to CCR2B and regulates its internalization. PLoS One. 2010 Aug 17;5(8):e12212. doi: 10.1371/journal.pone.0012212. PMID: 20808917; PMCID: PMC2923182.

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