Name : Mouse CD19 Protein

Product Source :
Recombinant Mouse CD19 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Arg19-Gly287.[Accession | P25918]

Molecular Weight :
The protein has a predicted MW of 30.7 kDa. Due to glycosylation, the protein migrates to 55-68 kDa based on Tris-Bis PAGE result.

Endotoxin Level :
Less than 1EU per ug by the LAL method.

Purity :
> 90% as determined by Tris-Bis PAGE

Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Product Concentration :
Tris-Bis PAGE Mouse CD19 on Tris-Bis PAGE under reduced condition. The purity is greater than 90%.

Background :
CD19 is a 95 kDa transmembrane glycoprotein that plays a central role in B cell activation and humoral immune responses.Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca2 stores.

Synonyms :
CD19; B4; CVID3; Leu-12; MGC12802

References & Citations :
(1)Maude S L, Teachey D T, Porter D L, et al. CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia[J]. Blood, 2015, 125(26):4017-23.

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