Name : Mouse CD163 Protein
Product Source :
Recombinant Mouse CD163 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Val39-Thr1045.[Accession | Q2VLH6-1]
Molecular Weight :
The protein has a predicted MW of 109.53 kDa. Due to glycosylation, the protein migrates to 120-150 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse CD163 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse CD163 is greater than 95% as determined by SEC-HPLC.
Background :
The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-specific protein and the upregulated expression of this receptor is one of the major changes in the macrophage switch to alternative activated phenotypes in inflammation. Accordingly, a high CD163 expression in macrophages is a characteristic of tissues responding to inflammation.
Synonyms :
M130; CD163 molecule; CD163; GHI/61; HbSR; MM130; RM3/1; SCARI1; sCD163
References & Citations :
(1) Etzerodt A, Moestrup SK. CD163 and inflammation: biological, diagnostic, and therapeutic aspects. Antioxid Redox Signal. 2013 Jun 10;18(17):2352-63. doi: 10.1089/ars.2012.4834. Epub 2012 Oct 19. PMID: 22900885; PMCID: PMC3638564.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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