Name : Human CD37 Protein
Product Source :
Recombinant Human CD37 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Ala113-Asn240.[Accession | P11049-1]
Molecular Weight :
The protein has a predicted MW of 15.72 kDa. Due to glycosylation, the protein migrates to 25-40 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human CD37 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
CD37 is a tetraspanin expressed prominently on the surface of B cells. It is an attractive molecular target exploited in the immunotherapy of B cell-derived lymphomas and leukemia. Currently, several monoclonal antibodies targeting CD37 as well as chimeric antigen receptor-based immunotherapies are being developed and investigated in clinical trials. Given the unique role of CD37 in the biology of B cells, it seems that CD37 constitutes more than a docking point for monoclonal antibodies, and targeting this molecule may provide additional benefit to relapsed or refractory patients.
Synonyms :
Tetraspanin-26; Tspan-26; CD37; CD37 molecule; GP52-40; MGC120234
References & Citations :
(1)Bobrowicz M, Kubacz M, Slusarczyk A, Winiarska M. CD37 in B Cell Derived Tumors-More than Just a Docking Point for Monoclonal Antibodies. Int J Mol Sci. 2020 Dec 15;21(24):9531. doi: 10.3390/ijms21249531. PMID: 33333768; PMCID: PMC7765243.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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