Name : Human CD300c/LMIR2 Protein

Product Source :
Recombinant Human CD300c/LMIR2 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Gly21-Arg183.[Accession | Q08708]

Molecular Weight :
The protein has a predicted MW of 18.94 kDa. Due to glycosylation, the protein migrates to 38-53 kDa based on Tris-Bis PAGE result.

Endotoxin Level :
Less than 1EU per μg by the LAL method.

Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC

Formulation :
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Product Concentration :
Tris-Bis PAGE Human CD300c on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human CD300c is greater than 95% as determined by SEC-HPLC.

Background :
CMRF35-like molecule-1 (CLM-1, also named CD300c) belongs to a receptor family mainly expressed in myeloid cells that include activating and inhibitory receptors. CLM-1 contains two ITIMs and a single immunoreceptor tyrosine-based switch motif (ITSM), although also displays a binding site for p85α regulatory subunit of PI3K.

Synonyms :
CLM-6; CLM6; CLM 6; CMRF35-A1; CMRF35A1; CMRF-35; CMRF35; IgSF16; CMRF35A1

References & Citations :
Ejarque-Ortiz A, Solà C, Martínez-Barriocanal Á, Schwartz S Jr, Martín M, Peluffo H, Sayós J. The Receptor CMRF35-Like Molecule-1 (CLM-1) Enhances the Production of LPS-Induced Pro-Inflammatory Mediators during Microglial Activation. PLoS One. 2015 Apr 30;10(4):e0123928. doi: 10.1371/journal.pone.0123928. PMID: 25927603; PMCID: PMC4415817.

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