Name : Mouse CD43 Protein
Product Source :
Recombinant Mouse CD43 Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Asp20-Gly248.[Accession | P15702]
Molecular Weight :
The protein has a predicted MW of 49.30 kDa. Due to glycosylation, the protein migrates to 75-120 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse CD43 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse CD43 is greater than 95% as determined by SEC-HPLC.
Background :
CD43 is a large transmembrane protein involved in T cell activation. Previous studies of CD43-/- mice in viral models have demonstrated a role for CD43 in Th1/Th2 skewing, activation of Foxp3 Treg, and T cell apoptosis. CD43 (leukosialin) is a large sialoglycoprotein abundantly expressed on the surface of most cells from the hematopoietic lineage. CD43 is directly involved in the contact between cells participating in a series of events such as signaling, adherence and host parasite interactions.
Synonyms :
Leukosialin; CD43; Ly-48; A630014B01Rik; Galgp; GPL115; LSN; Sialophorin; SPN
References & Citations :
(1) Alisson-Silva F, Mantuano NR, Lopes AL, Vasconcelos-Dos-Santos A, Vale AM, Costa MM, Cannon JL, Oliveira AC, Todeschini AR. CD43 sialoglycoprotein modulates cardiac inflammation and murine susceptibility to Trypanosoma cruzi infection. Sci Rep. 2019 Jun 13;9(1):8628. doi: 10.1038/s41598-019-45138-7. PMID: 31197200; PMCID: PMC6565700.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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