Name : Human CD72 Protein
Product Source :
Recombinant Human CD72 Protein is expressed from HEK293 with His tag at the N-Terminus. It contains Arg117-Asp359.[Accession | P21854]
Molecular Weight :
The protein has a predicted MW of 29.17 kDa. Due to glycosylation, the protein migrates to 32-40 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human CD72 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
CD72 (originally Lyb-2), a 45 kDa type II transmembrane glycoprotein. CD72 belongs to the calcium-dependent C-type lectin superfamily and shares sequence homology with CD23 (the B-cell-specific low-affinity Fc receptor for IgE) and the asialoglycoprotein receptors. It is expressed as a disulfide-linked homodimer from the pro-B through the mature B-cell stage, but it is downregulated on terminally differentiated plasma cells.
Synonyms :
Lyb-2; Lyb2; CD72;
References & Citations :
Parnes JR, Pan C. CD72, a negative regulator of B-cell responsiveness. Immunol Rev. 2000 Aug;176:75-85. doi: 10.1034/j.1600-065x.2000.00608.x. PMID: 11043769.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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