Name : Mouse ALK Protein
Product Source :
Recombinant Mouse ALK Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Ser19-Cys692.[Accession | P97793]
Molecular Weight :
The protein has a predicted MW of 101.11 kDa. Due to glycosylation, the protein migrates to 115-125 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22μm filtered solution in PBS, 10% Glycerol (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse ALK on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse ALK is greater than 95% as determined by SEC-HPLC.
Background :
Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy approaches are demonstrating both preclinical and clinical promises.
Synonyms :
ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246;
References & Citations :
Wang L, Lui VWY. Emerging Roles of ALK in Immunity and Insights for Immunotherapy. Cancers (Basel). 2020 Feb 12;12(2):426. doi: 10.3390/cancers12020426. PMID: 32059449; PMCID: PMC7072244.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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