Name : Cynomolgus CDH6/Cadherin-6 Protein
Product Source :
Recombinant Cynomolgus CDH6/Cadherin-6 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Thr22-Gly614.[Accession | G7MUQ7]
Molecular Weight :
The protein has a predicted MW of 67.10 kDa. Due to glycosylation, the protein migrates to 75-95 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Cynomolgus CDH6 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Cynomolgus CDH6 is greater than 95% as determined by SEC-HPLC. ELISA Data Immobilized Cynomolgus, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-CDH6 Antibody, Rabbit IgG Tag with the EC50 of 96.4ng/ml determined by ELISA.
Background :
Cadherin 6 (CDH6) is an adhesion molecule localizing to the endometrial luminal epithelial cell surface in the mid-secretory/receptive phase and knockdown of CDH6 in the Ishikawa cells (receptive endometrial epithelial cell line) compromises cell integrity.
Synonyms :
Cadherin-6; Cadherin6; K-cadherin; CDH6; CAD6; KCAD;
References & Citations :
Zhou W, Santos L, Dimitriadis E. Characterization of the role for cadherin 6 in the regulation of human endometrial receptivity. Reprod Biol Endocrinol. 2020 Jun 29;18(1):66. doi: 10.1186/s12958-020-00624-w. PMID: 32600462; PMCID: PMC7322878.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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