Name : Human CDH19 Protein

Product Source :
Recombinant Human CDH19 Protein is expressed from E.coli with MBP tag and Flag tag at the N-Terminus. It contains Gly44-His569.[Accession | Q9H159-1]

Molecular Weight :
The protein has a predicted MW of 100.89 kDa same as Tris-Bis PAGE result.

Endotoxin Level :
Less than 1EU per μg by the LAL method.

Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC

Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Product Concentration :
Tris-Bis PAGE Human CDH19 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human CDH19 is greater than 95% as determined by SEC-HPLC.

Background :
Cadherins play an important role in tissue homeostasis, as they are responsible for cell-cell adhesion during embryogenesis, tissue morphogenesis, differentiation and carcinogenesis. Cadherins are inseparably connected with catenins, forming cadherin-catenin complexes, which are crucial for cell-to-cell adherence. CDH19 is an evolutionarily conserved cadherin and may be involved in the early development of Schwann cells in the peripheral nervous system.

Synonyms :
Cadherin-19; Cadherin19; CDH7L2; cad19

References & Citations :
(1) Takahashi M, Osumi N. Identification of a novel type II classical cadherin: rat cadherin19 is expressed in the cranial ganglia and Schwann cell precursors during development. Dev Dyn. 2005 Jan;232(1):200-8. doi: 10.1002/dvdy.20209. PMID: 15580626.

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