Product Name: GW5074
Subtitle: C-Raf inhibitor,potent and selective
Biological Activity: Biological Activity of GW5074Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM). Displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm.
SMLES: C1=CC2=C(C=C1I)C(=CC3=CC(=C(C(=C3)Br)O)Br)C(=O)N2
CAS NO: 1127498-03-6
Standard In CHIKey: Haspin Kinase inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C15H8Br2INO2
M.Wt: 520.95
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/255/2/523
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 1 mM in ethanol and to 100 mM in DMSO
Storage: Desiccate at -20℃
Purity: >98%
Chemical Name: 3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one