Product Name: AT-101
Subtitle: BH3-mimetic,gossypol enantiomer
Biological Activity: Biological Activity of AT-101R-(-)-enantiomer of gossypol. Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to m
SMLES:
CAS NO: 1562338-42-4
Standard In CHIKey: QBKSWRVVCFFDOT-UHFFFAOYSA-NCaspase inhibitors
Standard InChI: InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3
Typrof Compound:
Appearance:
Formula: C30H30O8
M.Wt: 518.55
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/250/3/979
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage: Store at -20℃
Purity: >98%
Chemical Name: (-)-1,1,6,6,7,7-Hexahydroxy-3,3-dimethyl-5,5-bis(1-methylethyl)-[2,2-binaphthalene]-8,8-dicarboxaldehyde