Product Name: RITA (NSC 652287)
Subtitle: Mdm2-p53 interaction and p53 ubiquitination blocking
Biological Activity: Biological Activity of RITA (NSC 652287)Anti-tumor agent that binds wild-type p53 (Kd = 1.5 nM) preventing p53-MDM2 (HDM2) interaction. Induces p53 accumulation and stimulates apoptosis in tumor cell lines expressing wild-type p53 in vitro and in vivo. In
SMLES: C1=C(SC(=C1)C2=CC=C(O2)C3=CC=C(S3)CO)CO
CAS NO: 1352066-68-2
Standard In CHIKey: KZENBFUSKMWCJF-UHFFFAOYSA-NG-quadruplex inhibitors
Standard InChI: InChI=1S/C14H12O3S2/c15-7-9-1-5-13(18-9)11-3-4-12(17-11)14-6-2-10(8-16)19-14/h1-6,15-16H,7-8H2
Typrof Compound:
Appearance:
Formula: C14H12O3S2
M.Wt: 292.4
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/251/1/267
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO and to 25 mM in ethanol
Storage: Store at -20℃
Purity: >98%
Chemical Name: 5,5-(2,5-Furandiyl)bis-2-thiophenemethanol