Product Name: NSC 66811
Subtitle: MDM2 inhibitor
Biological Activity: Biological Activity of NSC 66811Potent MDM2 inhibitor (Ki = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.
SMLES: CC1=NC2=C(C=C1)C=CC(=C2O)C(C3=CC=CC=C3)NC4=CC=CC=C4
CAS NO: 451493-31-5
Standard In CHIKey: WEENRMPCSWFMTE-UHFFFAOYSA-NPolo-like Kinase PLK) inhibitors
Standard InChI: InChI=1S/C23H20N2O/c1-16-12-13-18-14-15-20(23(26)22(18)24-16)21(17-8-4-2-5-9-17)25-19-10-6-3-7-11-19/h2-15,21,25-26H,1H3
Typrof Compound:
Appearance:
Formula: C23H20N2O
M.Wt: 340.42
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/251/1/351
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO
Storage: Store at +4℃
Purity: >98%
Chemical Name: 2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol