Product Name: GNE0877
Subtitle: Potent and selective LRRK2 inhibitor
Biological Activity: Biological Activity of GNE0877Description GNE-0877 is a highly potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with Ki value of 0.7 nM. Targets LRRK2 IC50 Ki=0.7 nM
SMLES: FC(F)(C1=CN=C(N=C1NC)NC2=CN(C(C)(C#N)C)N=C2C)F
CAS NO: 229971-81-7
Standard In CHIKey: Naaddition)_HCO3- Cotransporter inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C14H16F3N7
M.Wt: 339.32
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/275/1/429
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: 2-methyl-2-(3-methyl-4-((4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)propanenitrile