Product Name: HKI 357
Subtitle:
Biological Activity: Biological Activity of HKI 357Potent, irreversible inhibitor of ErbB2 (HER2) and EGFR (IC50 values are 33 and 34 nM respectively). Suppresses ligand-induced EGFR autophosphorylation and cell proliferation in NCI-H1975 cells containing L858R and T790M muta
SMLES: ClC1=CC(NC(C2=C3)=C(C#N)C=NC2=CC(OCC)=C3NC(/C=C/CN(C)C)=O)=CC=C1OCC4=CC=CC(F)=C4
CAS NO: 202914-84-9
Standard In CHIKey: Cathepsin inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C31H29ClFN5O3
M.Wt: 574.05
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/275/2/1030
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO and to 25 mM in ethanol
Storage: Store at -20℃
Purity: >98%
Chemical Name: (2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide