Product Name: K 252a
Subtitle:
Biological Activity: Biological Activity of K 252aNon-selective protein kinase inhibitor; analog of staurosporine. Inhibits PKC (IC50 = 32.9 nM), Ca2+/calmodulin-stimulated phosphodiesterases (IC50 = 1.3 – 2.9 μM), MLCK (Ki = 20 nM) and receptor tyrosine kinases. Inhibits
SMLES: O[C@](C1)(C(OC)=O)[C@@]2(C)O[C@@H]1N3C4=C5N2C6=CC=CC=C6C5=C(CNC7=O)C7=C4C8=CC=CC=C38
CAS NO: 1224846-01-8
Standard In CHIKey: KOZFSFOOLUUIGY-UHOLRESSSA-NNeuronal Signaling inhibitors
Standard InChI: InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27?/m1/s1
Typrof Compound:
Appearance:
Formula: C27H21N3O5
M.Wt: 467.48
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/275/2/845
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 25 mM in DMSO
Storage: Desiccate at -20℃
Purity: >98%
Chemical Name: (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3,2,1-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester