Product Name: NVP-ADW742
Subtitle: Selective IGF-1R inhibitor
Biological Activity: Biological Activity of NVP-ADW742ATP-competitive inhibitor of IGF1R (IC50 in the range of 0.1-0.2 μM). Also inhibits c-Kit kinase activity (IC50 in the range of 3-5 μM). Exhibits a synergistic effect with Imatinib, enhancing the sensitivity of m
SMLES: C1CCN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6
CAS NO: 848463-13-8
Standard In CHIKey: p38 MAPK inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C28H31N5O
M.Wt: 453.58
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/275/1/31
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 50 mM in DMSO and to 10 mM in ethanol
Storage: Store at -20℃
Purity: >98%
Chemical Name: 5-[3-(Phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine