Product Name: PF-06447475
Subtitle:
Biological Activity: Biological Activity of PF-06447475Potent LRRK2 inhibitor (IC50 = 3 nM). Attenuates α-synuclein-induced dopaminergic neurodegeneration and neuroinflammation in G2019S-LRRK2 expressing rats. Also neuroprotective in wild type rats. Brain penetrant.
SMLES: N#CC1=CC=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=C1
CAS NO: 163768-50-1
Standard In CHIKey: 5 alpha Reductase inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C17H15N5O
M.Wt: 305.33
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/275/1/518
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 50 mM in DMSO
Storage: Store at +4℃
Purity: >98%
Chemical Name: 3-[4-(4-Morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile