Product Name: PF-573228
Subtitle: ATP-competitive FAK inhibitor
Biological Activity: Biological Activity of PF-573228Potent and selective inhibitor of focal adhesion kinase (FAK) (IC50 = 4 nM). Displays 50 – 250-fold selectivity for FAK over other protein kinases. Blocks serum and fibronectin-directed migration and decreases focal adhesio
SMLES: CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)CC4
CAS NO: 656247-18-6
Standard In CHIKey: MAPKAPK2 MK2) inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C22H20F3N5O3S
M.Wt: 491.49
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/275/1/274
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO
Storage: Store at +4℃
Purity: >98%
Chemical Name: 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone