Product Name: WZ3146
Subtitle: Mutant EGFR inhibitor, potent and irreversible
Biological Activity: Biological Activity of WZ3146Description WZ3146 is a potent and irreversible inhibitor of mutant EGFR with IC50 values of both 2 nM for EGFR(L858R) and EGFR(E746_A750). Targets EGFR(L858R) EGFR(E746_A750) IC50 2 nM 2 nM
SMLES: C=CC(NC1=CC=CC(OC2=NC(NC3=CC=C(N4CCN(C)CC4)C=C3)=NC=C2Cl)=C1)=O
CAS NO: 149908-53-2
Standard In CHIKey: NO Synthase inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C24H25ClN6O2
M.Wt: 464.95
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/275/1/171
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: N-(3-((5-chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)acrylamide