ANA 12
Product Name: ANA 12Subtitle: TrkB receptor antagonistBiological Activity: Biological Activity of ANA 12TrkB receptor antagonist. Demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50 values are 45.6…
KB SRC 4
Product Name: KB SRC 4Subtitle: Biological Activity: Biological Activity of KB SRC 4Potent and selective c-Src inhibitor (Ki = 44 nM); does not inhibit c-Abl at concentrations up to 125…
GSK2578215A
Product Name: GSK2578215ASubtitle: Biological Activity: Biological Activity of GSK2578215APotent LRRK2 inhibitor (IC50 values are 8.9 and 10.1 nM for LRRK2 mutant and wild-type LRRK2 respectively). Displays selectivity for LRRK2 over…
LM 22A4
Product Name: LM 22A4Subtitle: Biological Activity: Biological Activity of LM 22A4Potent tropomyosin-related kinase B (TrkB) agonist (IC50 = 47 nM). Induces activation of Trk, Akt and ERK in mouse hippocampus…
MLR 1023
Product Name: MLR 1023Subtitle: Biological Activity: Biological Activity of MLR 1023Selective allosteric activator of Lyn kinase (EC50 = 63 nM); displays no significant activity against a range of 47 other…
CZC 54252 hydrochloride
Product Name: CZC 54252 hydrochlorideSubtitle: Biological Activity: Biological Activity of CZC 54252 hydrochloridePotent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type…
DMH4
Product Name: DMH4Subtitle: Biological Activity: Biological Activity of DMH4Selective VEGFR-2 inhibitor (IC50 values are 161, 3558, 8038 and > 30000 nM for VEGFR-2, BMPR-I, AMPK and TGFβR-I respectively). Displays antiangiogenic…
TC-G 24
Product Name: TC-G 24Subtitle: Biological Activity: Biological Activity of TC-G 24Potent GSK-3β inhibitor (IC50 = 17 nM); displays selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). Increases liver…
3F8
Product Name: 3F8Subtitle: GSK-3β inhibitorBiological Activity: Biological Activity of 3F8Potent and selective GSK-3β inhibitor (IC50 values are 34 and 304 nM in the presence of 10 and 100 μM ATP…
5-Fluoroindirubinoxime
Product Name: 5-FluoroindirubinoximeSubtitle: Biological Activity: Biological Activity of 5-FluoroindirubinoximeInhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) (IC50 = 15 nM). Displays selectivity for FLT3 against 6 other kinases including EGFR. Displays…