Product Name: ZM 323881 HClSubtitle: Biological Activity: Biological Activity of ZM 323881 HClPotent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) activity. Selectively inhibits VEGFR-2 (IC50…
Product Name: SAR131675Subtitle: VEGFR3 inhibitor,selective and ATP-competitveBiological Activity: Biological Activity of SAR131675Description SAR131675 is an inhibitor of VEGFR3 with IC50/Ki of 23 nM/12 nM, respectively. Targets VEGFR3 IC50 23 nM…
Product Name: GW441756Subtitle: TrkA inhibitor,potent and selectiveBiological Activity: Biological Activity of GW441756Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays > 100-fold selectivity…
Product Name: Fostamatinib (R788)Subtitle: Spleen tyrosine kinase (Syk) inhibitorBiological Activity: SMLES: CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)(O)O)CCAS NO: Standard In CHIKey: BCRP inhibitorsStandard InChI: Typrof Compound: Appearance: Formula: C23H26FN6O9PM.Wt: 580.46General Tips: For obtaining a higher…
Product Name: KX2-391Subtitle: Src inhibitor,highly selectiveBiological Activity: Biological Activity of KX2-391Description KX2-391 is an inhibitor of Src (peptidomimetic class) with GI50 value of 9-60 nM in cancer cell lines. Targets…
Product Name: CP-673451Subtitle: PDGFRα/β inhibitor,potent and selectiveBiological Activity: Biological Activity of CP-673451Description CP-673451 is a selective inhibitor of PDGFRα/β with IC50 values of 10 nM/1 nM,respectively. Targets PDGFRβ PDGFRα c-Kit…
Product Name: Imatinib (STI571)Subtitle: Protein-tyrosine kinase inhibitorBiological Activity: Biological Activity of Imatinib (STI571)Description Imatinib is a selective inhibitor of protein-tyrosine kinase with IC50 values of 0.1, 0.1 and 0.025 μM,…
Product Name: NVP-ADW742Subtitle: Selective IGF-1R inhibitorBiological Activity: Biological Activity of NVP-ADW742ATP-competitive inhibitor of IGF1R (IC50 in the range of 0.1-0.2 μM). Also inhibits c-Kit kinase activity (IC50 in the range…
Product Name: Tyrphostin AG 879Subtitle: Biological Activity: Biological Activity of Tyrphostin AG 879Inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA. Decreases cellular proliferation in human muscular…
Product Name: Mubritinib (TAK 165)Subtitle: Biological Activity: Biological Activity of Mubritinib (TAK 165)Potent, irreversible human epithelial growth factor receptor 2 (ErbB2) inhibitor (IC50 = 6 nM) that displays > 4000-fold…