SU 16f
Product Name: SU 16fSubtitle: Biological Activity: Biological Activity of SU 16fPotent and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC50 = 10 nM) that displays > 14-fold, > 229-fold…
PP 3
Product Name: PP 3Subtitle: Biological Activity: Biological Activity of PP 3Negative control for the Src kinase inhibitor PP 2. Inhibits EGFR kinase (IC50 = 2.7 μM).SMLES: NC1=C2C(N(C3=CC=CC=C3)N=C2)=NC=N1CAS NO: Standard In…
HDS 029
Product Name: HDS 029Subtitle: Biological Activity: Biological Activity of HDS 029Potent inhibitor of the ErbB receptor family (IC50 values are 0.3, 0.5 and 1.1 nM for ErbB1 (EGFR), ErbB4 and…
PD 158780
Product Name: PD 158780Subtitle: Biological Activity: Biological Activity of PD 158780Potent inhibitor of ErbB receptor family tyrosine kinases (IC50 values are 0.008, 49 and 52 nM for EGFR, ErbB2 and…
BIBU 1361 dihydrochloride
Product Name: BIBU 1361 dihydrochlorideSubtitle: EGFR inhibitorBiological Activity: Biological Activity of BIBU 1361 dihydrochloridePotent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). Displays ~ 100-fold…
Ro 08-2750
Product Name: Ro 08-2750Subtitle: antagonist of nerve growth factor (NGF)Biological Activity: Biological Activity of Ro 08-2750Non-peptide inhibitor of NGF that binds the NGF dimer (KD ~ 1 μM) possibly causing…
GW 583340 dihydrochloride
Product Name: GW 583340 dihydrochlorideSubtitle: Biological Activity: Biological Activity of GW 583340 dihydrochloridePotent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 values are 0.01 and 0.014 μM respectively). Selectively inhibits growth of…
Demethylasterriquinone B1
Product Name: Demethylasterriquinone B1Subtitle: Biological Activity: Biological Activity of Demethylasterriquinone B1Selective insulin receptor (IR) activator (EC50 values are 3 – 6 μM for IRTK and 100 μM for IGF1R and…
Indirubin-3-oxime
Product Name: Indirubin-3-oximeSubtitle: Biological Activity: Biological Activity of Indirubin-3-oximeProtein kinase inhibitor; inhibits cyclin-dependent kinases (IC50 = 0.18 – 3.33 μM) and GSK-3β (IC50 = 0.19 μM). Inhibits CDK5- and GSK-3β-mediated…
K 252a
Product Name: K 252aSubtitle: Biological Activity: Biological Activity of K 252aNon-selective protein kinase inhibitor; analog of staurosporine. Inhibits PKC (IC50 = 32.9 nM), Ca2+/calmodulin-stimulated phosphodiesterases (IC50 = 1.3 – 2.9…