Name : Mouse ANGPT2/Angiopoietin-2 Protein
Product Source :
Recombinant Mouse ANGPT2/Angiopoietin-2 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Lys275-Phe496.[Accession | O35608]
Molecular Weight :
The protein has a predicted MW of 26.29 kDa. Due to glycosylation, the protein migrates to 30-35 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse ANGPT2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse ANGPT2 is greater than 95% as determined by SEC-HPLC.
Background :
Angiopoietin-2 (ANG-2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Mature ANG-2 is 478 amino acids in length.Ang2 is widely expressed during development, but it is restricted postnatally to highly angiogenic tissues such as the placenta, ovaries, and uterus. It is particularly abundant in vascular endothelial cells (EC) where it is stored in intracellular Weibel Palade bodies..
Synonyms :
AGPT2; ANG2; ANG-2; angiopoietin 2; Angiopoietin-2; angiopoietin-2a; angiopoietin-2B; angiopoitin 2; ANGPT2; Tie2-ligand
References & Citations :
(1)Wu X , Giobbie-Hurder A , Liao X , et al. Angiopoietin-2 as a Biomarker and Target for Immune Checkpoint Therapy[J]. Cancer Immunology Research, 2017, 5(1):17-28.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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