Name : Mouse PKM2 Protein
Product Source :
Recombinant Mouse PKM2 Protein is expressed from Baculovirus-Insect Cells with His tag at the N-terminus. It contains Pro2-Pro531.[Accession | NP_001240812.1]
Molecular Weight :
The protein has a predicted MW of 58.95 kDa same as Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in 20mM Tris, 500mM NaCl (pH 7.0). Normally 8% mannitol is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse PKM2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
Pyruvate kinase M2 (PKM2), a key rate-limiting enzyme of glycolysis, is a critical regulator in tumor metabolism. PKM2 has been demonstrated to overexpressed in various cancers and promoted proliferation and metastasis of tumor cells.
Synonyms :
Pkm; Pk3; Pykm; Pk-2; Pk-3
References & Citations :
Zhu S, Guo Y, Zhang X, Liu H, Yin M, Chen X, Peng C. Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics. Cancer Lett. 2021 Apr 10;503:240-248. doi: 10.1016/j.canlet.2020.11.018. Epub 2020 Nov 24. PMID: 33246091.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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