Name : Human CDH11/Cadherin 11 Protein
Product Source :
Recombinant Human CDH11/Cadherin 11 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Gly54-Thr617.[Accession | AAA35622]
Molecular Weight :
The protein has a predicted MW of 66.32 kDa. Due to glycosylation, the protein migrates to 67-70 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 90% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human CDH11 on Tris-Bis PAGE under reduced condition. The purity is greater than 90%.
Background :
CDH11 belongs to a group of transmembrane proteins that are principally located in adherens junctions. CDH11 mediates homophilic cell-to-cell adhesion, which may promote the development of cirrhosis. CDH11 expression was positively correlated with liver fibrosis in patients with cirrhosis, and could therefore be a prognostic factor in patients with liver fibrosis.
Synonyms :
Cadherin-11;OSF-4;Osteoblast cadherin;OB-cadherin;CDH11;CAD11OSF-4; CDHOB;OB
References & Citations :
(1) Ruan W, Pan R, Shen X, Nie Y, Wu Y. CDH11 promotes liver fibrosis via activation of hepatic stellate cells. Biochem Biophys Res Commun. 2019 Jan 8;508(2):543-549. doi: 10.1016/j.bbrc.2018.11.153. Epub 2018 Nov 30. PMID: 30509494.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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