Name : Mouse CDH3/Cadherin 3 Protein
Product Source :
Recombinant Mouse CDH3/Cadherin 3 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Glu100-Gly647.[Accession | P10287]
Molecular Weight :
The protein has a predicted MW of 64.68 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 90% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse CDH3 on Tris-Bis PAGE under reduced condition. The purity is greater than 90%.
Background :
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration.
Synonyms :
Cadherin-3;Placental cadherin;P-cadherin;CDH3;CDHP;HJMD;PCAD;PCADP-cadherin;CAD3
References & Citations :
(1) Zhou Y, Chi Y, Bhandari A, Xia E, Thakur PC, Qu J, Wang O, Zhang X. Downregulated CDH3 decreases proliferation, migration, and invasion in thyroid cancer. Am J Transl Res. 2020 Jun 15;12(6):3057-3067. PMID: 32655830; PMCID: PMC7344063.
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