Name : SARS-CoV-2 3CLpro/3C-like Protease Protein (P132H)
Product Source :
Recombinant SARS-CoV-2 3CLpro/3C-like Protease Protein (P132H) is expressed from E.coli without tag. It contains Ser1-Gln306(P132H).[Accession | YP_009725301.1]
Molecular Weight :
The protein has a predicted MW of 33.8 kDa same as Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Supplied as 0.22μm filtered solution in 25mM HEPES, 2.5mM DTT, 10% Glycerol (pH 7.5).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE SARS-CoV-2 3CLpro (P132H) on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase.
Synonyms :
3CL Protease; 3CL-Mpro; M Proteinase; Mpro
References & Citations :
(1) Pillaiyar T, Manickam M, Namasivayam V, Hayashi Y, Jung SH. An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy. J Med Chem. 2016 Jul 28;59(14):6595-628. doi: 10.1021/acs.jmedchem.5b01461. Epub 2016 Feb 29. PMID: 26878082; PMCID: PMC7075650.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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