Name : FITC-Labeled Human TPBG/5T4 Protein
Product Source :
Recombinant FITC-Labeled Human TPBG/5T4 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Ser32-Ser355.[Accession | Q13641-1]
Molecular Weight :
The protein has a predicted MW of 38.2 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Supplied as 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE FITC-Labeled Human TPBG on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
The oncofetal tumor-associated antigen 5T4 (TBGP) has been linked with CSC properties in several different malignancies. 5T4 has functional attributes that are relevant to the spread of tumors including through EMT, CXCR4/CXCL12, Wnt, and Hippo pathways which may all contribute through the mobilization of CSCs.
Synonyms :
M6P1; 5T4AG; WAIF1; TPBG; 5T4
References & Citations :
(1) Harrop R, O’Neill E, Stern PL. Cancer stem cell mobilization and therapeutic targeting of the 5T4 oncofetal antigen. Ther Adv Vaccines Immunother. 2019 Jan 25;7:2515135518821623. doi: 10.1177/2515135518821623. PMID: 30719508; PMCID: PMC6348545.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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