Name : Human MVK Protein
Product Source :
Recombinant Human MVK Protein is expressed from Baculovirus-Insect Cells with His tag and GST tag at the N-terminus and Strep-II tag at the C-terminus. It contains Met1-Leu396.[Accession | Q03426]
Molecular Weight :
The protein has a predicted MW of 72.23 kDa. The protein migrates to 55-70 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 90% as determined by Tris-Bis PAGE
Formulation :
Supplied as 0.22 μm filtered solution in 20mM Tris, 500mM NaCl, 2mM DTT, 10% glycerol (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human MVK on Tris-Bis PAGE under reduced condition. The purity is greater than 90%.
Background :
Mevalonate kinase (MK) is an essential enzyme in the mevalonate pathway which produces numerous cellular isoprenoids. The enzyme has been characterized both at the biochemical and the molecular level in a variety of organisms. Despite the fact that mevalonate kinase is not the rate-limiting enzyme in isoprenoid biosynthesis, its activity is subject to feedback regulation by the branch-point intermediates geranyldiphosphate, farnesyldiphosphate and geranylgeranyldiphosphate.
Synonyms :
MK; LRBP; POROK3; MVLK
References & Citations :
Houten SM, Wanders RJ, Waterham HR. Biochemical and genetic aspects of mevalonate kinase and its deficiency. Biochim Biophys Acta. 2000 Dec 15;1529(1-3):19-32. doi: 10.1016/s1388-1981(00)00135-9. PMID: 11111075.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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