Name : Human Netrin receptor DCC Protein
Product Source :
Recombinant Human Netrin receptor DCC Protein is expressed from HEK293 with hFc tag at the C-terminus. It contains His26-Asn1097.[Accession | P43146]
Molecular Weight :
The protein has a predicted MW of 144.27 kDa. Due to glycosylation, the protein migrates to 140-160 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human Netrin receptor DCC on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human Netrin receptor DCC is greater than 95% as determined by SEC-HPLC.
Background :
DCC (Deleted in Colorectal Cancer) is a single-pass transmembrane protein that belongs to the immunoglobulin superfamily. It was originally identified as a prognostic tumor marker and then subsequently found to be a receptor for netrin-1. DCC plays a key role in axon guidance and also in a number of other important cellular processes.
Synonyms :
DCC; IGDCC1;
References & Citations :
Finci L, Zhang Y, Meijers R, Wang JH. Signaling mechanism of the netrin-1 receptor DCC in axon guidance. Prog Biophys Mol Biol. 2015 Sep;118(3):153-60. doi: 10.1016/j.pbiomolbio.2015.04.001. Epub 2015 Apr 14. PMID: 25881791; PMCID: PMC4537816.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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