Name : Human N Cadherin Protein
Product Source :
Recombinant Human N Cadherin Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Asp160-Ala724.[Accession | NP_001783.2]
Molecular Weight :
The protein has a predicted MW of 88.56 kDa. Due to glycosylation, the protein migrates to 100-120 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 90% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human N Cadherin on Tris-Bis PAGE under reduced condition. The purity is greater than 90%.
Background :
Neural (N)-cadherin is a calcium-dependent single-chain transmembrane glycoprotein that mediates homotypic and heterotypic cell-cell adhesion. As an important member of the cadherin family, N-cadherin plays an important role in the developmental and functional regulation of the nervous system, brain, heart, skeletal muscles, blood vessels and hematopoietic microenvironment.
Synonyms :
CDH2; N-cadherin; Neural cadherin; CD325; CDHN; CDw325; NCAD;
References & Citations :
Cao ZQ, Wang Z, Leng P. Aberrant N-cadherin expression in cancer. Biomed Pharmacother. 2019 Oct;118:109320. doi: 10.1016/j.biopha.2019.109320. Epub 2019 Aug 12. PMID: 31545265.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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