Name : Biotinylated Human EPO R/Erythropoietin R Protein
Product Source :
Recombinant Biotinylated Human EPO R/Erythropoietin R Protein is expressed from HEK293 with hFc tag and Avi tag at the C-terminus. It contains Ala25-Pro250.[Accession | P19235-1]
Molecular Weight :
The protein has a predicted MW of 52.58 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Biotinylated Human EPO R on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Biotinylated Human EPO R is greater than 95% as determined by SEC-HPLC. ELISA Data Immobilized Human EPO, No Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Human EPO R, hFc Tag with the EC50 of 0.30μg/ml determined by ELISA.
Background :
The erythropoietin (epo) receptor is a member of the cytokine receptor family. It is expressed almost exclusively on erythroid precursor cells and controls the development of red blood cells. The epo receptor has no intrinsic kinase activity, but binds intracellular tyrosine kinases to elicit its signals. Alterations in the transmission of the signalling cascade lead to clinically abnormal red blood cell production.
Synonyms :
EPO-R; Erythropoietin R; EPO R; EPOR
References & Citations :
Tilbrook PA, Klinken SP. The erythropoietin receptor. Int J Biochem Cell Biol. 1999 Oct;31(10):1001-5. doi: 10.1016/s1357-2725(99)00071-0. PMID: 10582333.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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