Product Name: A 419259 trihydrochloride
Subtitle: LCK inhibitor, orally available
Biological Activity: Biological Activity of A 419259 trihydrochloridePotent Hck inhibitor (IC50 = 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including CD34+. Also inhibits acute myeloid leukemia (A
SMLES:
CAS NO: 182349-12-8
Standard In CHIKey: JAK_STAT Signaling inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C29H37Cl3N6O
M.Wt: 592
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/275/1/219
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in water and to 100 mM in DMSO
Storage: Desiccate at RT
Purity: >98%
Chemical Name: 7-[trans-4-(4-Methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-Pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride