Product Name: AV-412 free base
Subtitle: EGFR/ErbB2 kinase inhibitor
Biological Activity: Biological Activity of AV-412 free basePotent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases (IC50 values are 0.5-2, 19 and 41 nM, respectively). Also weak inhibitor of FLT1 and Src. Inhibits EGFR and ErbB2 autophosphorylation in vitro in NSCL
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CAS NO:
Standard In CHIKey: GABA Receptor inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C27H28ClFN6O
M.Wt: 507
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/275/1/381
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO and to 20 mM in 1eq. HCl
Storage: Store at -20℃
Purity: >98%
Chemical Name: N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-2-propenamide